Introducing the X-Plus 3

Whether you are seeking to improve mental performance (brain photobiomodulation) or body resilience and functions (systemic photobiomodulation), the X-Plus 3 on its own or in combination with a Neuro model will go a long way to help you.


X-Plus 3 Components

The X-Plus 3 consists of 4 main modules: the X-Plus Head module, the X-Plus Body module, and 2 633nm X-Plus nasal applicators.


The X-Plus Head Module

In everyday life and in sports, your visual processing ability, balance, and coordination is crucial. The X-Plus Head module sits comfortably on the occipital lobe and cerebellum, which are the areas of the brain that process these tasks.

The occipital lobe interprets information from the eyes and turns it into the world as a person sees it. It is responsible for visuospatial processing, distance, and depth perception. [1].

The cerebellum is another important structure of the brain.

Although the cerebellum accounts for approximately 10% of the brain’s volume, it contains over 50% of the total number of neurons in the brain. The cerebellum is involved in the following functions:

Maintenance of balance and posture. The cerebellum is important for making postural adjustments to maintain balance. It modulates commands to motor neurons to compensate for shifts in body position or changes in load upon muscles. [2]

Coordination of voluntary movements. Most movements are composed of different muscle groups acting together in a temporally coordinated fashion. One major function of the cerebellum is to coordinate the timing and force of these different muscle groups to produce fluid limb or body movements.[3]

Motor learning. The cerebellum is important for motor learning. The cerebellum plays a major role in adapting and fine-tuning motor programs to make accurate movements through a trial-and-error process (e.g. learning to hit a baseball or throwing a basketball accurately).[4]

Combined, the cerebellum and occipital lobe account for much of the brain’s processing ability for movements required for physical performance. Now imagine the ability to stimulate these two brain structures to improve your everyday life and boost athletic and sports performance in a convenient manner without side effects.


X-Plus Intranasal module

The nasal cavity is saturated with blood capillaries. Five major arteries connect directly to the circulatory system [5], making it the perfect location for systemic photobiomodulation.

The X-Plus 3 comes with two 633nm intranasal modules, enabling photobiomodulation of the blood capillary-rich nasal passageway. Additionally, our patented clip-on intranasal design enables usage almost anywhere and while on the move.

Why systemic circulation?

Intranasal photobiomodulation improves oxygenation and leads to increased adenosine triphosphate (ATP) levels in various tissues. [6]

Light energy absorbed by blood through the photobiomodulation process leads to an increase in nitric oxide (NO) release.[7]

Nitric oxide is one of the most important factors affecting microcirculation. This leads to increases in vasodilation which contributes to improved oxygen delivery to tissues , which is important for optimizing your health and sports performance.

The result of light-induced photodissociation of oxyhemoglobin also results in a significant enrichment of local tissue oxygenation. [8]

The systemic effect of photobiomodulation on circulation could be a consequence of positive alterations in the membrane properties of red blood cells (RBCs). Absorption of red/NIR light affects hydrogen bonds, which could induce structural changes in RBC membrane proteins. [9]

This in turn, results in an improvement of RBC structure, ATP content, and osmotic properties. [10]

Conclusively, the X-Plus 3 intranasal modules are powerful tools for internalizing photobiomodulation into your circulatory system.


The X-Plus Body module

We hypothesize that the X-Plus Body module could potentially help with the immune system when positioned on the sternum. A version of this has been used in our clinical trial to treat COVID-19, and the findings will be made public soon.

Preprint of Results: Link

Additionally, the X-Plus Body module can be positioned over joints and certain body parts, such as the shoulder or knees to provide anti-inflammatory relief.


Conclusion

The X-Plus 3 is a useful device for improving anyone’s quality of life, but an especially powerful tool for athletes and biohackers to maximize performance. In a competitive world where the smallest difference in mental and physical performance can mean either first place or everything else after, the X-Plus 3 is a powerful tool to try.


References

[1] – Rehman A, Al Khalili Y. Neuroanatomy, Occipital Lobe. [Updated 2021 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK544320/

[2, 3, 4] – Cerebellum (section 3, Chapter 5) neuroscience online: An electronic textbook for the Neurosciences: Department of Neurobiology and Anatomy – the University of Texas Medical School at Houston. Cerebellum (Section 3, Chapter 5) Neuroscience Online: An Electronic Textbook for the Neurosciences | Department of Neurobiology and Anatomy – The University of Texas Medical School at Houston. (n.d.). Retrieved February 20, 2022, from https://nba.uth.tmc.edu/neuroscience/m/s3/chapter05.html#:~:text=The%20cerebellum%20is%20important%20for,in%20order%20to%20maintain%20balance.&text=One%20major%20function%20of%20the,is%20important%20for%20motor%20learning.

[5] – Nguyen JD, Duong H. Anatomy, Head and Neck, Lateral Nasal Artery. [Updated 2021 Nov 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK546681/

[6], [7] – Lohr NL, Keszler A, Pratt P, Bienengraber M, Warltier DC, Hogg N. Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. J Mol Cell Cardiol. 2009 Aug;47(2):256-63. doi: 10.1016/j.yjmcc.2009.03.009. Epub 2009 Mar 25. PMID: 19328206; PMCID: PMC4329292.

[8] – Stadler I, Evans R, Kolb B, Naim JO, Narayan V, Buehner N, Lanzafame RJ. In vitro effects of low-level laser irradiation at 660 nm on peripheral blood lymphocytes. Lasers Surg Med. 2000;27(3):255-61. doi: 10.1002/1096-9101(2000)27:3<255::aid-lsm7>3.0.co;2-l. PMID: 11013387.

[9] – Szymborska-Małek K, Komorowska M, Gąsior-Głogowska M. Effects of Near Infrared Radiation on DNA. DLS and ATR-FTIR Study. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jan 5;188:258-267. doi: 10.1016/j.saa.2017.07.004. Epub 2017 Jul 12. PMID: 28723592.

[10] – Walski T, Dyrda A, Dzik M, Chludzińska L, Tomków T, Mehl J, Detyna J, Gałecka K, Witkiewicz W, Komorowska M. Near infrared light induces post-translational modifications of human red blood cell proteins. Photochem Photobiol Sci. 2015 Nov;14(11):2035-45. doi: 10.1039/c5pp00203f. PMID: 26329012.