Research & Collaboration

Studies with Vielight technology

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  • Alzheimer’s Disease (Dementia)

Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function and Resting-State Functional Connectivity in Patients with Dementia: A Pilot Trial
Institutes – University of California San Francisco & the Veterans Affairs USA

[ Published Study (Photomedicine and Laser Surgery, 2018) ]

Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report
Co-authoring institutes – Harvard Medical School, Boston University School of Medicine

[ Published Study (Photomedicine and Laser Surgery, 2015) ]

Vielight Neuro RX Gamma – Pivotal Phase III Clinical Trial
Co-institutes – St Michael’s Hospital, Toronto

[ Clinical Trial Information Link (Clinicaltrials.gov – subsidiary of the US National Library of Medicine) ] (228 participants | 3 years | Ongoing)

Revitalizing Cognition in Older Adults at Risk for Alzheimer’s Disease With Near-Infrared Photobiomodulation

Institutes – University of Florida, University of Arizona, National Institute on Aging (NIA)

[ Clinical Trial Information Link (US National Library of Medicine) ] (168 participants | 5 years | Registration)

Impact of Photobiomodulation (PBM) on Biomarkers of Alzheimer’s Disease
Institutes – University of California San Francisco

[ Clinical Trial Information Link (Clinicaltrials.gov – subsidiary of the US National Library of Medicine) / UCSF Clinical Trials ] (16 participants | 1.5 years | Ongoing)

  • Traumatic Brain Injury / Concussion

Transcranial Photobiomodulation Treatment Effects In Former Athletes With Repetitive Head Hits
Institutes – Department of Neurology, University of Utah

[ Published Abstract Link (Archives of Clinical Neuropsychology) | Research Interview Link ]

Changes in Brain Function and Structure After Self-Administered Home Photobiomodulation Treatment in a Concussion Case
Institutes – VA Advanced Imaging Research Center, San Francisco VA Health Care System, Departments of Radiology & Biomedical Imaging and Psychiatry & Behavioral Sciences, University of California, San Francisco

[ Published Study Link (Frontiers, Neurology, 2020) | National Center for Biotechnology Information Link ]

Photobiomodulation to Improve Cognition in TBI, With fMRI
Institutes – Boston Veterans Affairs Research Institute

[ Clinical Trial Information Link (US National Library of Medicine) ] (20 participants | 1 years | Ongoing)

  • Parkinson’s Disease

Improvements in clinical signs of Parkinson’s disease using photobiomodulation: A prospective proof-of-concept study
Institutes – University of Sydney, University of New South Wales, Griffith University

[ Published Study Link (Liebert, 2021) ]

Pilot Intervention With Near Infrared Stimulation
Institutes – University of Florida

[ Clinical Trial Information Link (US National Library of Medicine) ] (135 participants | 4 years | Ongoing)

Evaluation of dose of Photobiomodulation (Light) Therapy and Physiotherapy for Improving Quality of Life Outcomes and Mobility in Parkinson’s Disease (Pilot)
Institutes – University of Sydney, University of Brisbane

[ Clinical Trial Information Link (Australian New Zealand Clinical Trial Registry) ] (16 participants | 1.5 years | Ongoing)

  • PTSD and Gulf War Illness

Improvements in Gulf War Illness Symptoms After Near-Infrared Transcranial and Intranasal Photobiomodulation: Two Case Reports
Institutes – University of California San Francisco & the Veterans Affairs USA

[ Published Study Link (Military Medicine, 184, 9/10:5, 2019) ]

  • Autism Spectrum Disorder (ASD)

Transcranial Photobiomodulation for the Treatment of Children with Autism Spectrum Disorder (ASD): A Retrospective Study
Institutes – Neurodevelopment Division, Istituto di Neuroscienze, Italy, Department of Psychiatry, Albert Einstein College of Medicine, NY

[ Published Study Link (MDPI Children, May 2022) ]

  • Covid-19

Vielight RX Plus for the Treatment of COVID-19 Respiratory Symptoms (COVIDLight)
Various clinical sites

[ Pre-print of Results ] (280 participants | 1 years | Ongoing)

  • Brain EEG Modulation and Cellular Effects

Near-Infrared Photobiomodulation of Living Cells, Tubulin, and Microtubules In Vitro
Institutes – Department of Physics and the Department of Chemistry, University of Alberta | Scholes Lab, Department of Chemistry, Princeton University, Princeton, NJ, United States | Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy | Vielight Inc

[ Published Study Link (Frontiers in Medical Technology, 2022) ]

Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations: a pilot exploratory study
Institutes – Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

[ Published Study Link (Nature, Scientific Reports, 2019) | National Center for Biotechnology Information Link ]

Exploring the Effects of Near Infrared Light on Resting and Evoked Brain Activity in Humans Using Magnetic Resonance Imaging
Institutes – University of Sydney

[ Published Study Link (Elsevier, December 2019) ]

Modulation of cortical oscillations using 10hz near-infrared transcranial and intranasal photobiomodulation: a randomized sham-controlled crossover study

[ Abstract Text Link (Brain Stimulation Journal, December 2021) ]

Location

Research Affiliation

Disclaimer: The published research links are independent information sources about photobiomodulation. No representation is made regarding Vielight devices or their capabilities.

Brain (transcranial) Photobiomodulation (tPBM)

Penetration

Transcranial photobiomodulation : simulation of dosimetry
Harvard Psychiatry Department, Harvard Medical School : [ Link ]

Red and NIR light dosimetry in the human deep brain
Institute of Chemical Sciences and Engineering, Switzerland : [ Link 1 | Link 2 ]

Photon Penetration Depth in Human Brains
The University of Southern California : [ Link ]

Monte Carlo analysis of the enhanced transcranial penetration using distributed near-infrared emitter array.
Institute of Biomedical Engineering, Chinese Academy of Medical Science : [ Link ]

Transcranial Red and Near Infrared Light Penetration in Cadavers
State University of New York Downstate Medical Center : [ Link ]

Cellular Effects

Photobiomodulation Directly Benefits Primary Neurons Functionally Inactivated by Toxins
Medical College of Wisconsin : [ Link ]

Neuroprotective effects of photobiomodulation : Evidence from assembly/disassembly of the Cytoskeleton
University of Sydney : [ Link ]

Photobiomodulation – mitochondrial ROS generation and calcium increase in neuronal synapses.
Lin-Kou Medical Center, Taiwan : [ Link ]

Infrared neural stimulation and functional recruitment of the peripheral Nerve
Department of Biomedical Engineering, Case Western Reserve University : [ Link ]

Cognition

Effect of Transcranial Low-Level Light Therapy vs Sham Therapy Among Patients With Moderate Traumatic Brain Injury
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston : [ Link ]

Brain Photobiomodulation Therapy: a Narrative Review
Department of Medical Physics, Tabriz University of Medical Sciences : [ Link ]

Psychological benefits with near infrared light to the forehead: a pilot study on depression
The Department of Psychiatry, Harvard Medical School and the Laboratory for Psychiatric Biostatistics, McLean Hospital : [ Link ]

Cognitive Enhancement by Transcranial Photobiomodulation Is Associated With Cerebrovascular Oxygenation of the Prefrontal Cortex
Department of Psychology, Institute for Neuroscience, University of Texas : [ Link ]

Mitochondrial Dysfunction-Near-Infrared Photobiomodulation as a Potential Therapeutic Strategy
Department of Research, National Neuroscience Institute, Singapore : [ Link ]

Transcranial Photobiomodulation For The Management Of Depression: Current Perspectives
Department of Psychiatry, NYU Langone School of Medicine, New York, NY, USA : [ Link ]

Increased Functional Connectivity Within Intrinsic Neural Networks in Chronic Stroke Following Treatment With Red/Near-Infrared Transcranial Photobiomodulation
Boston University School of Medicine, Harvard Medical School : [ Link ]

Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis
Wellman Center for Photomedicine, Massachusetts General Hospital : [ Link ]

Shining light on the head : Photobiomodulation for brain disorders
Wellman Center for Photomedicine, Massachusetts General Hospital : [ Link ]

Improved cognitive function after transcranial, light-emitting diode treatments in chronic, traumatic brain injury: two case reports
Boston University, School of Medicine : [ Link ]

Augmentation of cognitive brain functions with transcranial lasers
Department of Psychology and Institute for Neuroscience, University of Texas : [ Link ]

Neurological and psychological applications of transcranial lasers and LEDs
Department of Neurology and Neurotherapeutics, University of Texas : [ Link ]

Novel Methods

A novel method of applying NIR light intracranially, impact on dopaminergic cell survival
University of Sydney, CEA-Leti : [ Link ]

Low Level Systemic (via blood) Photobiomodulation

General research

Blood contains circulating cell-free respiratory competent mitochondria
Université de Montpellier : [ Link ]

Interplay between up-regulation of cytochrome-c-oxidase and hemoglobin oxygenation induced by near-infrared laser
University of Austin at Texas : [ Link ]

Red/Near Infrared Light Stimulates Release of an Endothelium Dependent Vasodilator and Rescues Vascular Dysfunction
US Veterans Affairs : [ Link ]

Low-Level Light Therapy Protects Red Blood Cells Against Oxidative Stress and Hemolysis During Extracorporeal Circulation
Regional Specialist Hospital, Poland : [ Link ]

How Photons Modulate Wound Healing via the Immune System
King’s College London (KCL), University of London : [ Link ]

Randomized, Double-Blind, and Placebo-Controlled Clinic Report of Intranasal Low-Intensity Laser Therapy on Vascular Diseases
Ministry of Education, Key Laboratory of Laser Life Science, China : [ Link ]

Blood Laser Irradiation : current state and future perspectives
ABER Institute, Helsinki, Finland : [ Link ]

Intravenous Laser Blood Irradiation
MH Weber : [ Link ]

Applications of Intranasal Low Intensity Laser Therapy In Sports Medicine
Journal of Innovative Optical Health Sciences, World Scientific : [ Link ]

Formation of gigantic mitochondria in human blood lymphocytes under the effect of a low level laser source
Institute on Laser and Informatic Technologies of Russian Acad. : [ Link ]

Irradiation with He-Ne laser increases ATP level in cells cultivated in vitro
National Cancer Research Centre of the Academy of Medicine and Science : [ Link ]

Photobiomodulation Mechanisms

Photobiomodulation—Underlying Mechanism and Clinical Applications : [ Link ]

Therapeutic Photobiomodulation: Nitric Oxide and a Novel Function of Mitochondrial Cytochrome C Oxidase : [ Link ]

Mechanisms of Low Level Light Therapy : [ Link ]

Basic Photomedicine : [ Link ]

The Nuts and Bolts of Low Level Light Therapy : [ Link ]

Disclaimer: Some of the research information pertains to ongoing clinical trials. No representation is made regarding Vielight devices or their capabilities beyond published results.

Please note that the Neuro Gamma device is not the same as the Neuro RX Gamma that is currently being used in our clinical trials.
The RX Gamma is intended to be fully compliant with regulatory requirements for a medical device and will not be available without regulatory clearance. The “Neuro RX Gamma” is therefore a different product from the “Neuro Gamma”.