At the moment, there are no pharmacological treatments for Autism Spectrum Disorder. There is a growing interest in non-pharmacological approaches, such as brain photobiomodulation.

This animation explores the results of an Autism Spectrum Disorder clinical study using the Vielight Neuro Duo, conducted by Dr Stefano Pallanti, a Stanford University Professor and Director of Istituto di Neuroscienze, Florence, Italy.

Introduction to the Study

Data was reported and analyzed from 21 patients, 13 males and 8 females with an average age of 9.1. The age range is 5 to 15 years old.

The study was conducted over six months at home.

Participants used the Vielight Neuro Duo with its two protocols, the Alpha 10 hertz protocol and the Gamma 40 hertz protocol.

Both Alpha and Gamma protocols were administered each day, one in the morning and one in the evening. Each session had a duration of 20 min, during which children were involved in stimulating activities, such drawing, coloring, reading, playing games, or doing homework.

Key Results

Findings show that after 6 months, transcranial-intranasal brain PBM was associated with:

  • reduction in ASD severity, as shown by a decrease in CARS scores (p < 0.001).
  • reduction in noncompliant behavior
  • reduction in parental stress
  • reduction in behavioral and cognitive rigidity
  • improvement in attentional functions and in sleep quality.

Secondary Benefits

These improvements not only enhanced the lives of the patients but also greatly reduced stress among their parents, as measured by the SDAG scale, creating a more peaceful and effective environment for growth.

How It Works

But how does this specific photobiomodulation device work? The Vielight Neuro Duo emits an optimal irradiance, amongst the highest in the industry with the 810 nanometer wavelength to penetrate the skull and reach the brain, transcranially and intranasally. The Vielight Neuro Duo’s design is patented and specifically targets the Default Mode Network or DMN, to improve connectivity between its nodes.

The default mode network is crucial in understanding autism because individuals with autism spectrum disorder have been observed to have alterations in their DMN, potentially contributing to difficulties in social interactions and understanding others’ perspectives.

Research suggests that atypical connectivity within the DMN may underlie the characteristic challenges in social communication and repetitive behaviors seen in autism.

Additionally, the two different pulsing modes, Alpha and Gamma are found to have different effects in this research. The alpha protocol promotes relaxation, reducing rigidity and improving sleep. Meanwhile, the gamma protocol boosts cognitive functions, aiding in better attention.”

Safety and Future Directions

From a safety perspective the treatment has been well-tolerated with minimal side effects, making it a safe option. While the results are promising, further research, including neuroimaging, is necessary to confirm these findings and understand the underlying changes better.


In conclusion, the Vielight Neuro Duo offers a new horizon for ASD, combining safety with effectiveness. With more research, this device could pave the way for a personalized treatment approach in neurodevelopmental disorders.

Read the full study here: